FROM THE NMRF RESEARCH LAB:  New Discoveries and Potential Areas of Study

With the creation of the new NMRF research lab + office space in Suite 2C of the Wellness Center, Dr. Bodor and his research team are already making progress on exciting new discoveries with respect to the regenerative treatments being used in current NMRF clinical studies

Platelet-rich plasma (PRP) treatments are leading the industry in orthobiologics – the application of biologic therapies for orthopedic applications. The widespread use of PRP, though, has raised a number of questions in the minds of researchers and physicians like Dr. Bodor including:

  • What is the most effective concentration of PRP?
  • What is the correct dosage for each injection?
  • How many platelets qualify an injection as beneficial?
  • How do co-administered substances (e.g. radiopaque dyes) influence platelet function?

Ryan Dregalla and Yvette Uribe are working diligently to begin answering these, and other highly relevant questions through the careful collection and examination of scientific data about PRP. Cell counting is an extremely important component is stem cell research. Thanks to the recent purchase of a flow cytometer, Dregalla and Uribe can more readily determine the viability of cells within each dose of the therapeutic cocktail of PRP. This data informs the effectiveness of the treatment and supports their work to develop protocols around standardization of treatments. Notoriously hard to use and interpret, the NMRF is fortunate to have Ryan Dregalla, PhD and founder of Dregalla Medical Technologies leading our research lab efforts with flow cytometry.

In addition to working with cell counting and concentrations for PRP, he is also incorporating the flow cytometer in a cell counting project for our Bone Marrow Aspirate Concentrate (BMAC) clinical studies. This data will help to determine whether or not the cell counts correlate with the clinical outcomes.

The NMRF is eagerly anticipating additional studies in our research pipeline that will examine more closely the cellular activity of the PRP, including an analysis of platelet interactions with the nucleus pulposus of the intervertebral disc, the catabolic and anabolic processes which are associated and the development of improved mechanisms to aspirate and process adipose tissue for regenerative treatments.