The Nap Medical Research Foundation (NMRF)’s research team has submitted a new paper for publication in the Spine Journal regarding their findings on utilizing stem cells to repair spinal discs while using different conditions of platelet-rich plasma (PRP). To read more about this important research, see our article “NMRF Researchers Make New Discovery in Using PRP to Repair Spinal Discs” on page ___ [will insert page number when Newsletter is formatted].
The research team has two book chapters in the works: one on thoracic procedures and one detailing NMRF’s findings on cervical procedures. Stay tuned for publication announcements.
Anesthetics and Platelet Article:
Our manuscript titled “Short-Term Exposure of Platelets to Commonly Used Anesthetics Results in Platelet Dysfunction” is in the process of final edits and approval for submission. This study highlights the clinical importance of anesthetic selection when using platelet-rich plasma (PRP) as a therapeutic agent. Historically, anesthetics have been shown to have deleterious effects on several nucleated cell types. However, these compounds have never been assessed in relation to platelets. Our research identified numerous markers of platelet dysfunction following brief exposure of platelets to anesthetics, which translates to a reduction in the therapeutic value of the platelet. Consequently, clinical outcomes reported for PRP in conditions where certain anesthetics were used may be suboptimal and explain inconsistencies in the literature regarding the efficacy of PRP in the treatment of orthopedic conditions. The Napa Medical Research Foundation staff intends to submit the completed manuscript to the American Journal of Sports Medicine for peer-review in the coming weeks.
ACL Study Approved:
During the NMRF Board Meeting held in February, Directors unanimously approved initial funding for the first year of a 10-year study titled “Bone Marrow Aspirate Concentrate Injection vs. Surgical Reconstruction for Acute ACL Tears: A Prospective Observational Cohort Study”. The objective of the study is to compare the outcomes of ultrasound-guided bone marrow aspirate (BMAC) injections against surgical reconstruction in the treatment of partial and complete, acute anterior cruciate ligament (ACL) tears.
Last month the study received IRB approval from UC Davis School of Medicine and the Foundation has just approved sponsoring the entire study cycle. Funds for this project will be raised specifically for the ACL Repair Study.
According to Dr. Tracy Hoeg, lead researcher on the project, “It is a very exciting study we have been planning for almost 2 years now. We have numerous physicians involved now who look forward to getting this study started. We have already seen amazing results with the BMAC in repairing the native ACL. It is a 10-year study looking at the long-term outcomes of the BMAC injection vs. surgical reconstruction.”